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What Is Detoxination®?

A Breakthrough Protocol for the 21st-Century Health Crisis

The History of Detoxination

The Detoxination Protocol was born from over 40 years of clinical work, environmental research, and biological detoxification breakthroughs. It was developed to address one of the most overlooked causes of chronic illness: bioaccumulated toxins stored in fat tissue, interfering with metabolism, immunity, and neurological function.

Pioneers in naturopathic medicine, environmental health, and orthomolecular therapy began observing that traditional detox methods weren’t enough. The body needed strategic help to mobilize and eliminate fat-soluble toxicants—many of which had been accumulating for decades.



Through careful testing and thousands of clinical applications, the Detoxination Protocol was established. It has since helped thousands of individuals worldwide regain health, energy, and cognitive clarity—by safely releasing and removing what their bodies could not detox on their own.

How It Works: The Core Mechanism

Detoxination®: Your Path to Better Health

Detoxination is more than a detox—it’s a physiological recalibration. It restores the body's ability to eliminate what is hurting it.

The protocol follows a six-stage sequence that targets the root cause of toxic overload:

  1. Niacin-Facilitated Lipolysis
    High-dose nicotinic acid (vitamin B3) triggers the release of toxins trapped in fat cells by initiating a
    rebound lipolysis response.
  2. Cardio & Sauna Activation
    Light exercise increases circulation. A
    deep, strategic sauna session follows to promote excretion through sweat and circulation to the liver.
  3. Supportive Nutrient Staging
    Vitamins A, C, D, E, B-complex, B1, minerals, and mitochondrial cofactors are provided to support detox enzymes and protect tissues.
  4. Hepatic Conjugation & Bile Flow
    The liver tags and processes released toxicants using methylation, glucuronidation, sulfation, and other pathways—often requiring cofactor support.
  5. Intestinal Binding & Toxin Capture
    Binders like
    clinoptilolite (zeolite), charcoal, or cholestyramine are timed to catch toxins in the gut before they’re reabsorbed via the enterohepatic circulation.
  6. Mitochondrial & Nervous System Recovery
    Nutrients like NAD precursors, phospholipids, and antioxidants repair damage to mitochondria, neurotransmitters, and membranes disrupted by years of toxic exposure.


Blogs

Stay informed with our Blog & Resources, where we share expert insights on detoxification, wellness, and the Detoxination® Protocol. Explore articles, research updates, and practical tips to enhance your detox journey. Whether you're a practitioner or an individual seeking better health, our resources provide valuable knowledge to support you.

By Keith Carpenter February 27, 2025
Detoxification is essential for maintaining optimal health, as our bodies accumulate toxins from environmental exposure, food, and lifestyle habits. The Detoxination® protocol , developed by Dr. David E. Root , is a scientifically backed method that utilizes niacin, exercise, and sauna therapy to mobilize and eliminate toxins stored in fat cells. This blog explores the research and mechanisms behind this powerful detox process and its benefits.

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